January 9, 2016

Selected publications

Valk E; Örd M; Faustova I; Loog M (2023). CDK signaling via non-conventional CDK phosphorylation sites. Molecular Biology of the Cell [forthcoming].

Faustova I, Örd M, Kiselev V, Fedorenko D, Borovko I, Macs D, Pääbo K, Lõoke M, Loog M. (2022) A synthetic biology approach reveals diverse and dynamic CDK response profiles via multisite phosphorylation of NLS-NES modules. Sci Adv.  Aug 19;8(33):eabp8992.

Philip J, Örd M, Silva A, Singh S, Diffley JF, Remus D, Loog M, & Ikui AE. (2022). Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. ELife, 11.

Asfaha JB, Örd M, Carlson CR, Faustova I, Loog M, Morgan DO. (2022) Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription. Curr Biol. Jan 10;32(1):256-263.e4. 

Böhm M, Killinger K, Dudziak A, Pant P, Jänen K, Hohoff S, Mechtler K, Örd M, Loog M, Sanchez-Garcia E, Westermann S. (2021). Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle. Elife. Jul 26;10:e67390. 

Faustova I, Bulatovic L, Matiyevskaya F, Valk E, Örd M, and Loog M. (2021) A new linear cyclin docking motif that mediates exclusively S-phase CDK-specific signaling.  EMBO Journal. Nov 19:e105839

Örd M, Faustova I, Loog M. (2020) The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV. Sci Rep. ;10(1):16944.

Bandyopadhyay S, Bhaduri, S, Örd M, Davey N E, Loog M, and Pryciak P M. (2020). Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo. Curr. Biol. Sep 24.

Örd M, Puss KK, Kivi R, Möll K, Ojala T, Borovko I, Faustova I, Venta R, Valk E, Kõivomägi M, Loog M. (2020) Proline-Rich Motifs Control G2-CDK Target Phosphorylation and Priming an Anchoring Protein for Polo Kinase Localization. Cell Rep. Jun 16;31(11):107757.

Venta R, Valk E, Örd M, Košik O, Pääbo K, Maljavin A, Kivi R, Faustova I, Shtaida N, Lepiku M, Möll K, Doncic A, Kõivomägi M, and Loog M. (2020) A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision. Nat Commun. Apr 15;11(1):1836.

Örd M, Möll K, Agerova A, Kivi R, Faustova I, Venta R, Valk E, Loog M. (2019) Multisite phosphorylation code of CDK. Nature Struct Mol Biol. Jul;26(7):649-658.

Örd M, Venta R, Möll K, Valk E, Loog M. (2019) Cyclin-Specific Docking Mechanisms Reveal the Complexity of M-CDK Function in the Cell Cycle. Molecular Cell. Jul 11;75(1):76-89.

Örd M, Loog M. (2019) How the cell cycle clock ticks. Mol Biol Cell. Jan 15;30(2):169-172.

Doncic A, Atay O, Valk E, Grande A, Bush A, Vasen G, Colman-Lerner A, Loog M, Skotheim JM. (2015) Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition. Cell. Mar 12;160(6):1182-95.

Bhaduri S, Valk E, Winters MJ, Gruessner B, Loog M, Pryciak PM. (2015) A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry. Curr Biol. Feb 2;25(3):316-25.

Valk E, Venta R, Ord M, Faustova I, Kõivomägi M, Loog M. (2014) Multistep phosphorylation systems: tunable components of biological signaling circuits. Mol Biol Cell. Nov 5;25(22):3456-60.

Kõivomägi M, Ord M, Iofik A, Valk E, Venta R, Faustova I, Kivi R, Balog ER, Rubin SM, Loog M. (2013) Multisite phosphorylation networks as signal processors for Cdk1. Nature Struct Mol Biol. 20(12), 1415-24.

McGrath DA, Balog ER, Kõivomägi M, Lucena R, Mai MV, Hirschi A, Kellogg DR, Loog M, Rubin SM. (2013) Cks confers specificity to phosphorylation-dependent CDK signaling pathways. Nature Struct Mol Biol. 20(12), 1407-14.

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Balog ERM., Rubin SM., Morgan DO, and Loog M. (2011) Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. Nature, Oct 12. doi: 10.1038.

Kõivomägi M, Valk E, Venta R, Iofik A, Lepiku M, Morgan D, and Loog M. (2011). Dynamics of Cdk1 substrate specificity during the cell cycle. Molecular Cell, 42(5), 610-23.

Loog M, and Morgan DO. (2005). Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates. Nature, 434(7029), 104 – 108.